広島大学 大学院統合生命科学研究科
食品衛生微生物学 島本研究室
発表論文
2024
1. Caigoy, J. C., Shimamoto T., Shimamoto T. Devepolment of a simple allele-specific PCR for the detection of pathogenic Vibrio cholerae O1 and O139 in seafood. Journal of Agriculturere and Food Research, 18, 101458 (2024)
2. Xedzro, C., Shimamoto T., Shimamoto T. Antimicrobial resistance and genotypic attributes of virulence among Vibrio spp. isolated from Japanese retail seafood. Journal of Agriculture and Food Research, 18,101449(2024)
2023
1. Soliman, A. M., Nariya, H., Tanaka, D., Shimamoto, T., Shimamoto, T. A Novel Single-Tube Eicosaplex/Octaplex PCR System for the Detection of Extended-Spectrum β-Lactamases, Plasmid-Mediated AmpC β-Lactamases, and Integrons in Gram-Negative Bacteria. Antibiotics, 12, 90 (2023)
2. Xedzro, C., Kimura, T., Shimamoto T., Ahmed A. M., Shimamoto T. Comparative molecular profiling of antimicrobial resistance and phylogenetic characterization of multidrug-reisistant Escherichia coli isolated from meat sources in 2009 and 2021 in Japan. International Journal of Food Microbiology, 391-393, 110146 (2023)
3. Xedzro, C., Shimamoto, T., Shimamoto, T. Predominance of Multidrug-Resistant Gram-Negative Bacteria Isolated from Supermarket Retail Seafood in Japan. Microorganisms, 11, 2935 (2023)
2022
1. Hammad, A.M., Eltahan, A., Hassan, H.A., Abbas, N.H., Hussien, H., Shimamoto, T. Loads of coliforms and fecal coliforms and characterization of thermotolerant Escherichia coli in fresh raw milk cheese. Foods, 11, 332 (2022)
2. Hammad, A.M., Aly, S.S., Hassan, H.A., Abbas, N.H., Eltahan, A., Khalifa, E., Shimamoto, T. Occurrence, phenotypic and molecular characteristics of vancomycin-resistant enterococci isolated from retail raw milk in Egypt. Foodborne Pathogens and Disease, 19, 192-198 (2022)
3. Caigoy, J. C., Shimamoto, T., Mukhopadhyay, A.K., Shinoda, S., Shimamoto, T. Sequence polymorphisms in Vibrio cholerae HapR affwct biofilm formation under aerobic and anaerobic conditions. Applied and Environmental Microbiology, 88, e0104422 (2022)
4. Soliman, A.M., Ramadan, H., Yu, L., Hisatsune, J., Sugai, M., Elnahriry, S.S., Nariya, H., El-Domany, R. A., Shimamoto, T., Jackson, C. R., Shimamoto T. Complete genome sequences of two Escherichia coli clinical from Egypt carrying mcr-l on IncP and IncX4 plasmids. Frontiers in Microbiology, 13, 989045 (2022)
2021
1. Sadek, M., Soliman, A. M., Nariya, H., Shimamoto, T., Shimamoto, T. Genetic characterization of carbapenemase-producing Enterobacter cloacae complex and Pseudomonas aeruginosa of food of animal origin from Egypt. Microbial Drug Resistance, 27, 196-203. (2021)
2. Soliman, A.M., Nariya, H., Tanaka, D., Yu, L., Hisatsune, J., Kayama, S., Kondo, K., Sugai, M., Shimamoto, T., Shimamoto, T. Vegetable-derived carbapenemase-producing high-risk Klebsiella pneumoniae ST15 and Acinetobacter baumannii ST2 clones in Japan: co-existence of blaNDM-1, blaOXA-66, blaOXA-72, and AbaR4-like resistance island from the same sample. Applied and Environmental Microbiology, 87, e02166-20 (2021)
3. Soliman, A.M., Ramadan, H., Zarad, H.O., Sugawara, Y., Yu, L., Sugai, M., Shimamoto, T., Hiott, L.M., Frye, J.G., Jackson, C.R., Shimamoto, T. Co-production of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt. Antimicrobial Agents and Chemotherapy, 65, e02084-20 (2021)
4. Sekiya, H., Okada, M., Tamai, E., Shimamoto, T., Shimamoto, T., Nariya, H. A putative amidase endolysin encoded by the Clostridium perfringens st13 exhibit specific lytic activity and synergizes with muramidase endolysin Psm. Antibiotics, 10, 245 (2021)
5. Adel, W.A., Ahmed, A.M., Hegazy,Y., Torky, H.A., Shimamoto,T. High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt. Antibiotics, 10, 881 (2021)
6. Hammad, A. M., Eltahan, A., Khalifa, E., Abbas, N. H., Shimamoto, T. Toxigenic Potential of Bacillus cereus Strains Isolated from Retail Dairy Products in Egypt. Foodborne Pathogens and Disease, 18, 655-660 (2021)
7. Gawish, M.F., Ahmed, A.M., Torky, H.A., Shimamoto, T. Prevalence of extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica from retail fishes in Egypt: A major threat to public health. International Journal of Food Microbiology, 351, 1092689 (2021)
8. 島本 整．市販野菜・果物由来の薬剤耐性菌の検出と解析．動物用抗菌剤研究会報, 43, 16-25(2021)
2020
1. Sadek, M., Poirel, L., Nordmann, P., Nariya, H., Shimamoto, T., Shimamoto, T. Draft genome sequence of a mcr-1/IncI2-carrying multidrug-resistant Escherichia coli B1: ST101 isolated from meat and meat products in Egypt. Journal of Global Antimicrobial Resistance, 20, 41-42 (2020)
2. Soliman, A. M., Zarad, H. O., Nariya, H., Shimamoto, T., Shimamoto, T. Genetic analysis of carbapenemase-producing Gram-negative bacteria isolated from a university teaching hospital in Egypt. Infection, Genetics and Evolution, 77, 104065 (2020)
3. Soliman, A. M., Maruyama, F., Zarad, H. O., Ota, A., Nariya, H., Shimamoto, T., and Shimamoto, T. Emergence of a Multidrug-Resistant Enterobacter hormaechei Clinical Isolate from Egypt Co-Harboring mcr-9 and blavim-4. Microorganisms, 8, 595 (2020)
4. Khalifa, H. O., Soliman, A. M., Saito, T., Kayama, S., Yu, L., Hisatsune, J., Sugai, M., Nariya, H., Ahmed, A. M., Shimamoto, T., Masumoto, T., Shimamoto, T. First Report of Foodborne Klebsiella pneumoniae Coharboring blaVIM-1, blaNDM-1, and mcr-9. Antimicrobial Agents Chemother, 64, e00882-20 (2020)
5. Sadek, M., Nariya, H., Shimamoto, T., Kayama, S., Yu, L., Hisatsune, J., Sugai, M., Nordmann, P., Poirel, L., and Shimamoto, T. First Genomic Chracterization of blaVIM-1 and mcr-9-Coharbouring Enterobacter hormaechei Isolated from Food of Animal Origin. Pathogens, 9, E687 (2020)
6. Soliman, A. M., Ramadan, H., Ghazy E., Yu, L., Hisatsune, J., Kayama, S., Sugai M., Nariya, H., Shimamoto, T., Jackson, C. R., Shimamoto, T. Emergence of Salmonella Genomic Island 1 Variant SGi1-C in a Multidrug-Resistant Clinical Isolate of Klebsiella pneumoniae ST485 from Egypt. Antimicrobial Agents and Chemotherapy, 64, e01055-20 (2020)
7. Soliman, A.M., Ramadan, H., Sadek, M., Nariya, H., Shimamoto, T., Hiott, L. M., Frye, J. G., Jackson, C. R., Shimamoto, T. Draft genome sequence of a bla NDM-1 - and bla OXA-244 -carrying multidrug-resistant Escherichia coli D-ST69 clinical isolate from Egypt, Journal of Global Antimicrobial Resistance, 22,832-834 (2020)
8. Sadek, M., Poirel, L., Nordmann, P., Nariya, H., Shimamoto, T., Shimamoto, T. Genetic characterization of NDM-1 and NDM-5-producing Enterobacteriales from retail chicken meat in Egypt, Journal of Global Antimicrobial Resistance, 23, 70-71 (2020)
2019
1. Oreiby, A., Khalifa, H., Eid, A., Ahmed, A., Shimamoto, T., Shimamoto T. Staphylococcus aureus and bovine mastitis: molecular typing of methicillinresistance and clinical description of infected quarters. Journal of the Hellenic Veterinary Medical Society, 70, 1511-1516 (2019)
2. Oreiby, A., Khalifa, H., Eid, A., Ahmed, A., Shimamoto, T., Shimamoto T. Clinical and molecular characterization of both methicillin-resistant andsensitive staphylococcus aureus mastitis. Journal of the Hellenic Veterinary Medical Society, 70, 1743-1748 (2019)
3. Saad, A. M., Soliman, A. M., Kawasaki, T., Fujie, M., Nariya, H., Shimamoto, T., Yamada, T. Systemic method to isolate large bacteriophages for use in biocontrol of a wide-range of pathogenic bacteria. Journal of Bioscience and Bioengineering, 127, 73-78 (2019)
4. Soliman, A. M., Shimamoto, T., Nariya, H., Shimamoto, T. Emergence of Salmonella genomic island 1 variant SGI1-W in a clinical isolate of Providencia stuartii from Egypt. Antimicrobial Agents and Chemotherapy, 63, e01793-18 (2019)
5. Khalifa, H. O., Soliman, A. M., Ahmed, A. M., Shimamoto, T., Nariya, H., Matsumoto, T., Shimamoto, T. High prevalence of antimicrobial resistance in Gram-negative bacteria isolated from clinical settings in Egypt: recalling for judicious use of conventional antimicrobials in developing nations. Microbial Drug Resistance, 25, 371-385 (2019)
2018
1. Hammad, A. M., Moustafa, A. H., Mansour, M. M., Fahmy, B. M., Hamada, M. G., Shimamoto, T., Shimamoto, T. Molecular and phenotypic analysis of hemolytic Aeromonas strains isolated from food in Egypt revealed clinically important multidrug resistance and virulence profiles. Journal of Food Protection, 81, 1015-1021 (2018)
2. Soliman, A. M., Saad, A. M., Ahmed, A. M., Al-bauir, A., Hussein, A., Shimamoto, T., Nariya, H., Shimamoto, T. Occurrence of Salmonella genomic island 1 (SGI1) in two African Proteus mirabilis strains isolated from diseased chicken flocks. Infection, Genetics and Evolution, 62, 8-10 (2018)
3. Saad, A. M., Askora, A., Soliman, A. M., Nariya, H., Kawasaki, T., Fujie, M., Shimamoto, T., Yamada, T. Full genome sequence of a polyvalent bacteriophage infecting strains of Shigella, Salmonella, and Escherichia. Archives of Virology, 163, 3207-3210 (2018)
2017
1. Hammad, A. M., Shimamoto, T., Shimamoto T. (2017) Emergence of a novel β-lactamase in food of animal origin: Characterisation of SHV-111, from a cheese isolateof Klebsiella pneumoniae with an amino acid substitution in a strictly conservedposition (P174S) in the Ω-loop. J. Med. Microbiol., 66(1): 96-97.
2. Khalifa, H. O., Soliman, A. M., Ahmed, A. M., Shimamoto, T., Hara, T., Ikeda, M.,Kuroo, Y., Kayama, S., Sugai, M., Shimamoto, T. (2017) High carbapenem resistance in clinical Gram-negative pathogens isolated in Egypt. Microb. Drug Resist., 23(7): 838-844.
3. Soliman, A. M., Ahmed, A. M., Shimamoto, T., El-Domony, R. A., Nariya, H., Shimamoto, T. (2017) First report in Africa of two clinical isolates of Proteus mirabilis carrying Salmonella genomic island (SGI1) variants, SGI1-PmABB and SGI1-W. Infect. Genet. Evol.,51: 132-137.
2016
1. Khalifa, H. O., Soliman, A. M., Ahmed, A.M., Shimamoto, T., Shimamoto T. (2016) NDM-4 and NDM-5-Producing Klebsiella pneumoniae Coinfection in a 6-Month-Old Infant. Antimicrobial Agents and Chemotherapy. 60(7): 4416-4417.
2. Soliman, A. M., Khalifa, H. O., Ahmed, A.M., Shimamoto, T., Shimamoto T. (2016) Emergence of an NDM-5-producing clinical Escherichia coli isolate in Egypt. International Journal of Infectious Diseases. 48: 46-48.
3. Khalifa, H. O., Ahmed, A. M., Oreiby A.F., Eid A.M., Shimamoto, T., Shimamoto, T. (2016) Characterisation of the plasmid-mediated colistin resistance gene mcr-1 in Escherichia coli isolated from animals in Egypt. International Journal of Antimicrobial Agents. 47:413-414.
4. Elnahriry, S. S., Khalifa, H. O., Soliman, A. M., Ahmed, A. M., Hussein, A. M., Shimamoto, T., Shimamoto, T. (2016) Emergence of Plasmid-Mediated Colistin Resistance Gene mcr-1 in a Clinical Escherichia coli Isolate from Egypt. Antimicrobial Agents and Chemotherapy. 60: 3249-3250.
2015
1. Ahmed, A. M. and Shimamoto, T. (2015) Molecular analysis of multidrug resistance in Shiga toxin-producing Escherichia coli O157:H7 isolated from meat and dairy products. Int. J. Food Microbiol. 193: 68-73
2. Ahmed, A. M. and Shimamoto, T. (2015) Molecular characterization of multidrug-resistant Shigella spp. of food origin. Int. J. Food Microbiol. 194: 78-82.
3. Hammad, A. M., Hassan, H. A. and Shimamoto, T. (2015) Prevalence, antibiotic resistance and virulence of Enterococcus spp. in Egyptian fresh raw milk cheese. Food Control 50: 815-820.
4. Ahmed, A. M., Maruyama, A., Khalifa, H. O., Shimamoto, T., Shimamoto T. (2015) Seafood as a Reservoir of Gram-negative Bacteria Carrying Integrons and Antimicrobial Resistance Genes in Japan. Biomed Environ Sci 28: 924-927.
5. Khalifa H. O., Kamimoto M.,Shimamoto T., Shimamoto T. (2015) Antimicrobial Effects of Blueberry, Raspberry, and Strawberry Aqueous Extracts and their Effects on Virulence Gene Expresssion in Vibrio cholerae. Phytotherapy Research 29: 1791-1797.
2014
1. Ahmed, A. M., Shimamoto, T. and Shimamaoto, T. (2014) Characterization of integrons and resistance genes in multidrug-resistant Salmonella enterica isolated from meat and dairy products in Egypt. Int. J. Food Microbiol.189: 39-44.
2. Kamimoto, M., Nakai, Y., Tsuji, T., Shimamoto, T.,Shimamoto, T. (2014) Efficacy of Ethanol-based Sanitizer Containing Persimmon Extract on Norovirus and its Surrogate Bacteriophage MS2
3. Kamimoto, M., Nakai, Y., Tsuji, T. and Shimamoto, T. (2014) Antiviral effects of persimmon extract on human norovirus and its surrogate, bacteriophage MS2. J. Food Sci. 79(5): M941-946.
4. Ahmed, A. M., and Shimamoto, T. (2014) Isolation and molecular characterization of Salmonella enteric, Escherichia coil O157:H7 and Shigella spp. from meat and dairy products in Egypt. Int.J. Food Microbiol. 168-169: 57-62.
5. Hammad, A. M., Shimamoto, T., and Shimamoto, T. (2014) Genetic characterization of antibiotic resistance and virulence factor in Enterococcus spp. from Japanese retail ready-to-eat raw fish. Food Microbiol. 38: 62-6.
2013
1. Shimamoto,T., Ahmed, A. M. and Shimamoto, T. (2013) A novel retron of Vibrio parahaemolyticus is closely related to retron-Vc95 of Vibrio cholerae. J. Microbiol. 51(3): 323-8.
2. Ahmed, A. M., Shimamoto, T., and Shimamoto, T. (2013) Molecular characterization of multidrug-registant avian pathogenic Escherichia coil isolated from septicemic broilers. Int. J. Med. Microbiol. 303(8): 475-83.
2012
1. Ahmed, A. M., and Shimamoto, T. (2012) Genetic analysis of multiple antimicrobial resistance in Salmonella isolated from diseased broiler in Egypt. Microbiol. Immunol. 56(4): 254-61.
2. Hammad, A. M., Watanabe, W., Fujii, T., Shimamoto, T.(2012) Occurrence and characteristics of methicillin-resistant and –susceptible Staphylococcus aureus and methicillin-resistantcoagulase-negative staphylococci from Japanese retail ready-to-eat raw fish. Int.J.Food Microbiol. 156(3): 286-9.
2011
1. Das, R., Shimamoto, T., Hosen, S. M. Z., Arifuzzaman, M. (2011) Comparative study of different msDNA(multicopy single-strandedDNA) structures and Phylogenetic comparison of reverse transcriptases (RTs): evidence for vertical inheritance. Bioinformation. 7(4): 176-179.
2. Das, R., Shimamoto, T., Arifuzzaman, M. (2011) A novel msDNA (muli-copy single-stranded DNA) strain present in Yersinia frederiksenii ATCC 33641 contig01029 enteropathogenic bacteria with the genomic analysis of its retorn.
3. Hammad, A. M. and Shimamoto, T. (2011) Asymptomatic intramammary infection with multidrug-resistant Gram-negative bacteria in a research dairy farm: Incidence and genetic basis of resistance. J. Vet. Med. Sci. 73(8): 1089-1092.
4. Inouye, K., Tanimoto, S., Kamimoto, M., Shimamoto, T., Shimamoto, T. (2011) Two novel retron elements are replaced with retron-Vc95 in Vibrio cholerae. Microbiol. Immunol. 55(7): 510-513.
5. Ahmed, A. M. and Shimamoto, T. (2011) Molecular characterization of antimicrobial resistance in Gram-negative bacteria isolated from bovine mastitis in Egypt. Microbiol. Immunol. 55(5): 318-327.
2010
1. Ishida, Y., Ahmed, A. M., Mahfouz, N. B., Kimura, T., El-Khodery S. A., Moawad, A. A., Shimamoto T. (2010) Molecular analysis of antimicrobial resistance in Gram-negative bacteriaisolated from fish farms in Egypt. J. Vet. Med. Sci. 72(6): 727-734.
2.Hammad, A. M. and Shimamoto, T. (2010) Towards a compatible prbiotic-antibiotic combination therapy: assessment of antimicrobial resistance in the Japanese probiotics. J. Appl. Microbiol. 109(4): 1349-1360
2009
1. Ahmed, A. M., Younis, E. E. A., Ishida, Y., Shimamoto, T. (2009) Genetic basis of multidrug resistance in Salmonella enterica serovars Enteritidis and Typhimurium isolated from diarrheic calves in Egypt. Acta Trop. 111(2): 144-9
2. Hammad, A. M., Ishida, Y.and Shimamoto, T. (2009) Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese. J Food Prot. 72(3): 624-30
3. Ahamed, A. M., Ishida, Y. and Shimamoto, T.(2009) Molecular characterization of antimicrobial resistance in Salmonella isolated from animal in Japan. J Appl Microbilol. 106(2): 402-9.
4. Ahamed, A. M., Younis, E. E. A., Osman, S. A., Ishida, Y., El-Khodery, S. A. and Shimamoto, T.(2009) Genetic Ayalysis of antimicrobial resistance in Escherichia coil isolated from diarrheic neonatal calves. Vet Microbiol. 12:136(3-4): 397-402.
2008
1. Hammad, A. M., Ahmed, A. M., Ishida, Y. and Shimamoto T. (2008) First characterization and emergence of SHV-60 in raw milk of a healthy cow in Japan. J Vet Med Sci. 70(11): 1269-72.
2. Ahmed, A. M. and Shimamoto, T. (2008) Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37. Int. J. Antimicrob. Agents. 32(3): 256-61.
2007
1. Ahmed, A. M., Motoi, Y., Sato, M., Maruyama, A., Watanabe, H., Fukumoto, Y. and Shimamoto, T. (2007) Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes. Appl Environ Microbiol. 73(20): 6686-90.
2. Ahmed, A.M., Hussein, A. I. A. and Shimamoto, T. (2007) Proteus mirabilis clinical isolate harbouring a new variant of Salmonella genomic island 1 containing the multiple antibiotic resistance region. J. Antimicrob. Chemother. 59(2): 184-90.
著書・総説
2021
1. 島本 整．カキタンニンによるノロウイルスの不活化と抗ウイルス剤の開発「抗菌・抗ウイルス性能の材料への付与, 加工技術と評価」,
（株） 技術情報協会, 東京, pp343-351 (2021)
2. 島本 整. 食の安全と食中毒「SDGsに向けた生物生産学入門(三本木至宏 監修)」, 共立出版, 東京, pp208-211 (2021)
2018
1. 島本 整．食中毒の最新動向「序章」 医学と薬学, 75, 737-738 (2018)
2.島本 整．食中毒の最新動向「ノロウイルス」 医学と薬学, 75, 789-795 (2018)
2016
1. 島本 整. (2016) シリーズ匠の化学「日本文化に根付いた柿渋の化学」 化学と教育, 64(7):348-349
2.島本 整．(2016) 果樹研究最前線No.250「カキタンニンの抗ノロウイルス作用の発見」 果実日本, 71(9):8-11
2013
1. 神本真紀, 中井義昭, 辻 徹, 島本 敏, 島本 整. (2013) 柿渋の持つ抗ウイルス作用. フードケミカル, 29(2):35-40
2011
1. 島本 整. (2011) 遺伝子の姿「生命・食・環境のサイエンス」（江坂宗春 監修）共立出版, 東京. 1-4.
2. 島本 整. (2011) 食品添加物と環境ホルモン「生命・食・環境のサイエンス」（江坂宗春監修）共立出版, 東京. 172-174.
3. 島本 整, 島本 敏. (2011) 抗菌薬のMICと生菌整腸薬の適応は？ 薬局, 62(3):423-427.
2010
1. 島本 整. (2010) 農業領域で使用される抗菌薬と耐性菌汚染. 臨床と微生物, 37(6):679-683.
2.島本 整, 中野宏幸, 古澤修一, 他123名 (2010) 「食品微生物学辞典」(日本食品微生物学会監修) 中央法規出版, 東京.
特許
2022
1. 島本 整，辻 徹，吉田充史．「ノロウイルスおよびその代替ウイルスに対する抗ウイルス剤および抗ウイルス組成物」
（特許第7175467号，令和4年11月11日登録）
2020
1. 島本 整，森谷和郎．「抗ノロウイルス剤」（特許第6709030号，令和2年5月26日登録）
2017
1. 島本 整，沖中 泰，坂口剛正，辻 徹，中井義昭．「Antiviral Agent and Antiviral Composition」
（カナダ特許第2719358号，平成29年10月24日登録）
2. 島本 整，沖中 泰，坂口剛正，辻 徹，中井義昭．「抗ウイルス剤および抗ウイルス組成物」
（ベトナム特許第17715号，平成29年10月31日登録）
2016
1. 島本 整，神本真紀，中井義昭，辻 徹．｢カリン等抽出物を有効成分とする非エンベロープウイルスに対する抗ウイルス剤」
（特許第6047812号，平成28年12月2日登録）
2014
1. 島本 整，沖中 泰，坂口剛正，辻 徹，中井義昭．「A型インフルエンザウイルス属のエンベロープウイルスに対する抗ウイルス性衛生用繊維製品（特許第5571577号，平成26年7月4日登録）
2. 島本 整，沖中 泰，坂口剛正，辻 徹，中井義昭．「A型インフルエンザウイルス属のエンベロープウイルスに対する抗ウイルス剤および抗ウイルス用組成物」（特許第5670201号，平成26年12月26日登録）
2013
1. 島本 整，沖中 泰，坂口剛正，辻 徹，中井義昭．「エンテロウイルス属の非エンベロープウイルスに対する抗ウイルス剤および抗ウ イルス用組成物」（特許第5421901号，平成25年11月29日登録）
2012
1. 島本 整，辻 徹，中井義昭．「抗ノロウイルス剤およびこれを含有する組成物」（特許第5092145号, 平成24年9月28日登録）